| 1. | It can be prepared via a Grignard reaction between ethylmagnesium bromide and piperonylonitrile.
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| 2. | The modern method employs the Grignard reaction, using phenylmagnesium bromide and SbCl 3.
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| 3. | The Grignard reaction is an important means of preparing organic compounds from smaller precursor molecules.
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| 4. | Secondly, Grignard reactions, while exothermic, are typically conducted at low temperature for better selectivity.
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| 5. | This synthesis was the best way to make alcohols until the advent of the Grignard reaction in 1901.
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| 6. | The apparent increased reactivity of hypervalent molecules, contrasted with tetravalent analogues, has also been observed for Grignard reactions.
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| 7. | The Grignard reaction does not have this advantage because it is so reactive that it attacks indiscriminately from both sides.
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| 8. | The most common application of Grignard reagents is the alkylation of aldehydes and ketones, i . e . the Grignard reaction:
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| 9. | For instance in the E1cB elimination reaction and in organometallic chemistry in for instance a Grignard reaction or in alkyl lithium chemistry.
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| 10. | A synthesis of tolcapone proposed in 2008 begins with a Grignard reaction between a benzaldehyde derivative and p-tolyl magnesium bromide.
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